Imaging insights into basal ganglia function, Parkinson’s disease, and dystonia
Identifieur interne : 000A41 ( Main/Exploration ); précédent : 000A40; suivant : 000A42Imaging insights into basal ganglia function, Parkinson’s disease, and dystonia
Auteurs : A. Jon Stoessl ; Stephane Lehericy ; Antonio P. StrafellaSource :
- Lancet [ 0140-6736 ] ; 2014.
English descriptors
- KwdEn :
- Basal Ganglia (diagnostic imaging), Basal Ganglia (physiopathology), Brain Mapping (methods), Disease Progression, Dopamine (metabolism), Dystonia (diagnosis), Dystonia (physiopathology), Humans, Magnetic Resonance Imaging (methods), Magnetic Resonance Spectroscopy (methods), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Perfusion Imaging (methods), Positron-Emission Tomography (methods).
- MESH :
- chemical , metabolism : Dopamine.
- diagnosis : Dystonia, Parkinson Disease.
- diagnostic imaging : Basal Ganglia.
- methods : Brain Mapping, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Perfusion Imaging, Positron-Emission Tomography.
- physiopathology : Basal Ganglia, Dystonia, Parkinson Disease.
- Disease Progression, Humans.
Abstract
Recent advances in structural and functional imaging have greatly improved our ability to assess normal functions of the basal ganglia, diagnose parkinsonian syndromes, understand the pathophysiology of parkinsonism and other movement disorders, and detect and monitor disease progression. Radionuclide imaging is the best way to detect and monitor dopamine deficiency, and will probably continue to be the best biomarker for assessment of the effects of disease-modifying therapies. However, advances in magnetic resonance enable the separation of patients with Parkinson’s disease from healthy controls, and show great promise for differentiation between Parkinson’s disease and other akinetic-rigid syndromes. Radionuclide imaging is useful to show the dopaminergic basis for both motor and behavioural complications of Parkinson’s disease and its treatment, and alterations in non-dopaminergic systems. Both PET and MRI can be used to study patterns of functional connectivity in the brain, which is disrupted in Parkinson’s disease and in association with its complications, and in other basal-ganglia disorders such as dystonia, in which an anatomical substrate is not otherwise apparent. Functional imaging is increasingly used to assess underlying pathological processes such as neuroinflammation and abnormal protein deposition. This imaging is another promising approach to assess the effects of treatments designed to slow disease progression.
Url:
DOI: 10.1016/S0140-6736(14)60041-6
PubMed: 24954673
PubMed Central: 4454525
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000788
- to stream Pmc, to step Curation: 000788
- to stream Pmc, to step Checkpoint: 000471
- to stream PubMed, to step Corpus: 000697
- to stream PubMed, to step Curation: 000697
- to stream PubMed, to step Checkpoint: 000697
- to stream Ncbi, to step Merge: 001800
- to stream Ncbi, to step Curation: 001800
- to stream Ncbi, to step Checkpoint: 001800
- to stream Main, to step Merge: 000A44
- to stream Main, to step Curation: 000A41
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Imaging insights into basal ganglia function, Parkinson’s disease, and dystonia</title><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name></author><author><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stephane" last="Lehericy">Stephane Lehericy</name></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24954673</idno><idno type="pmc">4454525</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454525</idno><idno type="RBID">PMC:4454525</idno><idno type="doi">10.1016/S0140-6736(14)60041-6</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000788</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000788</idno><idno type="wicri:Area/Pmc/Curation">000788</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000788</idno><idno type="wicri:Area/Pmc/Checkpoint">000471</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000471</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000697</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000697</idno><idno type="wicri:Area/PubMed/Curation">000697</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000697</idno><idno type="wicri:Area/PubMed/Checkpoint">000697</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000697</idno><idno type="wicri:Area/Ncbi/Merge">001800</idno><idno type="wicri:Area/Ncbi/Curation">001800</idno><idno type="wicri:Area/Ncbi/Checkpoint">001800</idno><idno type="wicri:doubleKey">0140-6736:2014:Stoessl A:imaging:insights:into</idno><idno type="wicri:Area/Main/Merge">000A44</idno><idno type="wicri:Area/Main/Curation">000A41</idno><idno type="wicri:Area/Main/Exploration">000A41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Imaging insights into basal ganglia function, Parkinson’s disease, and dystonia</title><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name></author><author><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stephane" last="Lehericy">Stephane Lehericy</name></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></author></analytic><series><title level="j">Lancet</title><idno type="ISSN">0140-6736</idno><idno type="eISSN">1474-547X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal Ganglia (diagnostic imaging)</term><term>Basal Ganglia (physiopathology)</term><term>Brain Mapping (methods)</term><term>Disease Progression</term><term>Dopamine (metabolism)</term><term>Dystonia (diagnosis)</term><term>Dystonia (physiopathology)</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Magnetic Resonance Spectroscopy (methods)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Perfusion Imaging (methods)</term><term>Positron-Emission Tomography (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dystonia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Basal Ganglia</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Brain Mapping</term><term>Magnetic Resonance Imaging</term><term>Magnetic Resonance Spectroscopy</term><term>Perfusion Imaging</term><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Dystonia</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Disease Progression</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Recent advances in structural and functional imaging have greatly improved our ability to assess normal functions of the basal ganglia, diagnose parkinsonian syndromes, understand the pathophysiology of parkinsonism and other movement disorders, and detect and monitor disease progression. Radionuclide imaging is the best way to detect and monitor dopamine deficiency, and will probably continue to be the best biomarker for assessment of the effects of disease-modifying therapies. However, advances in magnetic resonance enable the separation of patients with Parkinson’s disease from healthy controls, and show great promise for differentiation between Parkinson’s disease and other akinetic-rigid syndromes. Radionuclide imaging is useful to show the dopaminergic basis for both motor and behavioural complications of Parkinson’s disease and its treatment, and alterations in non-dopaminergic systems. Both PET and MRI can be used to study patterns of functional connectivity in the brain, which is disrupted in Parkinson’s disease and in association with its complications, and in other basal-ganglia disorders such as dystonia, in which an anatomical substrate is not otherwise apparent. Functional imaging is increasingly used to assess underlying pathological processes such as neuroinflammation and abnormal protein deposition. This imaging is another promising approach to assess the effects of treatments designed to slow disease progression.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stephane" last="Lehericy">Stephane Lehericy</name><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A41 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A41 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4454525
|texte= Imaging insights into basal ganglia function, Parkinson’s disease, and dystonia
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24954673" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |